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KMID : 0383820160790010031
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Tuberculosis and Respiratory Diseases
2016 Volume.79 No. 1 p.31 ~ p.36
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Risk Factors for Mechanical Ventilation in Patients with Scrub Typhus Admitted to Intensive Care Unit at a University Hospital
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Moon Kyoung-Min
Han Min-Soo
Rim Ch`ang Bum
Lee Jun-Ho
Kang Min-Seok
Kim Ji-Hye
Kim Sang-Il
Jung Sun-Young
Cho Yong-Seon
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Abstract
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Background : The purpose of this study was to evaluate the risk factors for mechanical ventilation in the patients with
scrub typhus admitted to intensive care unit (ICU) at a university hospital.
Methods : We retrospectively selected and analyzed clinical data from the medical records of 70 patients (32 men, 38
women) admitted to the ICU with scrub typhus between 2004 and 2014. The patients had a mean±standard deviation
age of 71.2±11.1 years and were evaluated in two groups: those who had been treated with mechanical ventilation (the
MV group, n=19) and those who had not (the non-MV group, n=51). Mean ages of the MV group and the non-MV group
were 71.2±8.3 years and 71.2±11.1 years, respectively.
Results : Significant differences between the two groups were observed with respect to acute respiratory failure (p=0.008),
Acute Physiology and Chronic Health Evaluation (APACHE) II score (p=0.015), Sequential Organ Failure Assessment
(SOFA) score (p=0.013), death (p=0.014), and ICU duration (p<0.01). Multivariate analysis indicated that the following
factors were significantly associated with mechanical ventilation: acute respiratory failure (p=0.011), SOFA score
(p=0.005), APACHE II score (p=0.011), platelet count (p=0.009), and lactate dehydrogenase (LDH) (p=0.011).
Conclusion : Thus, five factors?acute respiratory failure, SOFA score, APACHE II score, platelet count, and LDH?can be
the meaningful indicators for mechanical ventilation for the patients with scrub typhus admitted to ICU.
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KEYWORD
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Scrub Typhus, Mechanical Ventilations, Intensive Care Units, APACHE, Blood Platelets, Lactate Dehydrogenase
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